The Opening Sequnces for Malcolm in the Middle are clips from movies, TV shows, etc. that play in the theme song of the show.
- Three women fighting a giant turtle: A scene from the movie One Million Years BC.
- Anime guy smiling in the rain: The character Shiogami from the movie Nazca.
- Monster coming out of the ocean: The Kraken from Clash of the Titans.
- Woman being held above the nest of a pterodactyl: Another scene from One Million Years BC.
- Anime Guy Skateboarding: Another scene from Nazca.
- Mud Monster grabbing a woman away from her boyfriend: A scene from Creature from the Haunted Sea.
- Skiing guy jumping off of a mountain in flames: Thrill Seekers
- Wrestling Match: Canadian Bret Hart wrestling Canadian Chris Benoit (locking him in his finishing move, The Sharpshooter), during the WCW World Heavyweight Championship Match at WCW Mayhem PPV in Toronto, Ontario, Canada.
- Robot head being put together: From the series Out of the Unknown, episode Liar!.
- Man Beating Brain Monster with Axe: From the movie The Brain From Planet Arous.
- Boxer knocking out referee: Cuban Pedro Cardenas fighting Canadian Willie DeWitt but accidentally KO'd referee Bert Lowes instead, during the 1982 North American Championships in Las Vegas.